1. Departments of Chemical Research, Endocrinology & Metabolism, and Analytical Research, Sigma Tau Pharmaceutical Industries S.p.A., Via Pontina Km 30.400, 00040 Pomezia, Italy, Department of Chemistry, Chemical Engineering and Materials, University of L'Aquila, L'Aquila, Italy, and S.IN-Soluzioni Informatiche S.a.s., Vicenza, Italy