Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling-Reference-Cited by-同舟云学术

Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

Published:2013-01-22 Issue:3 Volume:56 Page:781-795
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wittwer Matthias B.¹,Zur Arik A.¹,Khuri Natalia²,Kido Yasuto³,Kosaka Alan⁴,Zhang Xuexiang⁴,Morrissey Kari M.¹,Sali Andrej²,Huang Yong⁴,Giacomini Kathleen M.¹

Affiliation:

1. University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences RH 581, 1550 Fourth Street, San Francisco, California 94158, United States

2. University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences (QB3) BH 503B, 1700 Fourth Street, San Francisco, California 94158, United States

3. Drug−Drug Interaction Group, Drug Metabolism and Pharmacokinetics, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan

4. Optivia Biotechnology Inc., 115 Constitution Drive, Suite 7. Menlo Park, California 94025, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301302s

Reference58 articles.

1. Wiley Series in Drug Discovery and Development;You G.,2007

2. Membrane transporters in drug development

3. Organic Cation Transporters (OCTs, MATEs), In Vitro and In Vivo Evidence for the Importance in Drug Therapy