Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

Author:

Wittwer Matthias B.1,Zur Arik A.1,Khuri Natalia2,Kido Yasuto3,Kosaka Alan4,Zhang Xuexiang4,Morrissey Kari M.1,Sali Andrej2,Huang Yong4,Giacomini Kathleen M.1

Affiliation:

1. University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences RH 581, 1550 Fourth Street, San Francisco, California 94158, United States

2. University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences (QB3) BH 503B, 1700 Fourth Street, San Francisco, California 94158, United States

3. Drug−Drug Interaction Group, Drug Metabolism and Pharmacokinetics, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan

4. Optivia Biotechnology Inc., 115 Constitution Drive, Suite 7. Menlo Park, California 94025, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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