Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies-Reference-Cited by-同舟云学术

Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies

Published:2011-05-05 Issue:10 Volume:54 Page:3637-3649
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guantai Eric M.¹²,Ncokazi Kanyile¹,Egan Timothy J.¹,Gut Jiri³,Rosenthal Philip J.³,Bhampidipati Ravi⁴,Kopinathan Anitha⁴,Smith Peter J.²,Chibale Kelly¹⁵

Affiliation:

1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

2. Division of Pharmacology, University of Cape Town, Observatory 7925, South Africa

3. Department of Medicine, San Francisco General Hospital, University of California at San Francisco, San Francisco, California 94143, United States

4. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia

5. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200149e

Reference43 articles.

1. Drug resistant falciparum malaria: clinical consequences and strategies for prevention

2. Evidence of Artemisinin-Resistant Malaria in Western Cambodia

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