1. Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China, Department of Chemistry, Department of Life Sciences, and Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, Republic of China, and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, Republic of China