Metabolic Regio- and Stereoselectivity of Cytochrome P450 2D6 towards 3,4-Methylenedioxy-N-alkylamphetamines: in Silico Predictions and Experimental Validation-Reference-Cited by-同舟云学术

Metabolic Regio- and Stereoselectivity of Cytochrome P450 2D6 towards 3,4-Methylenedioxy-N-alkylamphetamines: in Silico Predictions and Experimental Validation

Published:2005-08-19 Issue:19 Volume:48 Page:6117-6127
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Keizers Peter H. J.¹,de Graaf Chris¹,de Kanter Frans J. J.¹,Oostenbrink Chris¹,Feenstra K. Anton¹,Commandeur Jan N. M.¹,Vermeulen Nico P. E.¹

Affiliation:

1. Leiden Amsterdam Center for Drug Research (LACDR)/Division of Molecular Toxicology and Division of Organic and Inorganic Chemistry, Department of Chemistry and Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050338%2B

Reference55 articles.

1. Oxygen and Xenobiotic Reductase Activities of Cytochrome P450

2. Where is Toxicology Headed in the Future?

3. Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs

4. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

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