2-Methylimidazol-1-yl-Substituted Analogs of Hexahydro-difenidol (HHD) and Hexahydro-sila-difenidol (HHSiD) as M3 Receptor-Preferring Muscarinic Antagonists: A Study on C/Si Bioisosterism-Reference-Cited by-同舟云学术

2-Methylimidazol-1-yl-Substituted Analogs of Hexahydro-difenidol (HHD) and Hexahydro-sila-difenidol (HHSiD) as M3 Receptor-Preferring Muscarinic Antagonists: A Study on C/Si Bioisosterism

Published:2002-08-08 Issue:18 Volume:21 Page:3727-3732
ISSN:0276-7333
Container-title:Organometallics
language:en
Short-container-title:Organometallics

Author:

Tacke Reinhold¹,Handmann Vera I.¹,Kreutzmann Kai¹,Keim Christine¹,Mutschler Ernst¹,Lambrecht Günter¹

Affiliation:

1. Institut für Anorganische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany, and Pharmakologisches Institut für Naturwissenschaftler, Biozentrum Niederursel, Universität Frankfurt, Marie-Curie-Strasse 9, Geb. N 260, D-60439 Frankfurt, Germany

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/om020346d

Reference26 articles.

1. Cyclohexy (4-fluorophenyl)(3-piperidinopropyl)silanol ((itp)-fluoro-hexahydro-sila-difenidol, p-F-HSSiD) and derivatives: synthesis and antimuscarinic properties

2. Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes

3. Stereoselective inhibition of muscarinic receptor subtypes by the enantiomers of hexahydro-difenidol and acetylenic analogues

4. Binding affinities of hexahydro-difenidol and hexahydro-sila-difenidol analogues at four muscarinic receptor subtypes: constitutional and stereochemical aspects

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