Design and Synthesis of N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities-Reference-Cited by-同舟云学术

Design and Synthesis of N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities

Published:2004-11-13 Issue:6 Volume:48 Page:2248-2250
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Devasthale Pratik V.¹,Chen Sean¹,Jeon Yoon¹,Qu Fucheng¹,Shao Chunning¹,Wang Wei¹,Zhang Hao¹,Cap Michael¹,Farrelly Dennis¹,Golla Rajasree¹,Grover Gary¹,Harrity Thomas¹,Ma Zhengping¹,Moore Lisa¹,Ren Jimmy¹,Seethala Ramakrishna¹,Cheng Lin¹,Sleph Paul¹,Sun Wei¹,Tieman Aaron¹,Wetterau John R.¹,Doweyko Arthur¹,Chandrasena Gamini¹,Chang Shu Y.¹,Humphreys W. Griffith¹,Sasseville Vito G.¹,Biller Scott A.¹,Ryono Denis E.¹,Selan Fred¹,Hariharan Narayanan¹,Cheng Peter T. W.¹

Affiliation:

1. Metabolic Diseases Chemistry, Metabolic Diseases Biology, Macromolecular Structure, Metabolism and Pharmacokinetics, Drug Safety Evaluation, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-5400

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0496436

Reference15 articles.

1. Hyperglycemia and cardiovascular disease in type 2 diabetes.

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3. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review

4. Pioglitazone

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