Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors: Lead Hopping Based on a Three-Dimensional Pharmacophore Model-Reference-Cited by-同舟云学术

Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors: Lead Hopping Based on a Three-Dimensional Pharmacophore Model

Published:2005-12-01 Issue:1 Volume:49 Page:80-91
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tsuchida Keiichi¹,Chaki Hisaaki¹,Takakura Tadakazu¹,Kotsubo Hironori¹,Tanaka Tadashi¹,Aikawa Yukihiko¹,Shiozawa Shunichi¹,Hirono Shuichi¹

Affiliation:

1. Discovery Laboratories and Research Laboratories, Toyama Chemical Co., Ltd., 4-1 Shimookui 2-chome, Toyama 930-8508, Japan, Department of Rheumatology, Faculty of Health Science, Kobe University School of Medicine, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142, Japan, Rheumatic Disease Division, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan, and School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050550d

Reference26 articles.

1. AP-1 – Introductory remarks

2. Studies on the contribution of c-fos/AP-1 to arthritic joint destruction.

3. F-actin binding site masked by the intramolecular association of vinculin head and tail domains

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