Synthesis of Malarial Plasmepsin Inhibitors and Prediction of Binding Modes by Molecular Dynamics Simulations-Reference-Cited by-同舟云学术

Synthesis of Malarial Plasmepsin Inhibitors and Prediction of Binding Modes by Molecular Dynamics Simulations

Published:2005-08-23 Issue:19 Volume:48 Page:6090-6106
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ersmark Karolina¹,Nervall Martin¹,Hamelink Elizabeth¹,Janka Linda K.¹,Clemente Jose C.¹,Dunn Ben M.¹,Blackman Michael J.¹,Samuelsson Bertil¹,Åqvist Johan¹,Hallberg Anders¹

Affiliation:

1. Department of Medicinal Chemistry, Uppsala University, BMC, Box 574, 751 23 Uppsala, Sweden, Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, 751 24 Uppsala, Sweden, Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW/ 1AA, UK, Medivir AB, Lunastigen 7, 141 44 Huddinge, Sweden, and Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, P.O. Box 100245 Gainesville, Florida 32610-0245

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050463l

Reference67 articles.

1. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden

2. Epidemiology of drug-resistant malaria

3. Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

4. Plasmodium falciparum: Effects of Proteinase Inhibitors on Globin Hydrolysis by Cultured Malaria Parasites

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