Unexpected DNA Affinity and Sequence Selectivity through Core Rigidity in Guanidinium-Based Minor Groove Binders
Author:
Affiliation:
1. School of Chemistry, Trinity College Dublin, Dublin 2, Ireland
2. Department of Chemistry, Georgia State University, Atlanta, Georgia 30302, United States
Funder
Higher Education Authority
Science Foundation Ireland
Trinity College Dublin
Consejeria de Educacion Cultura y Deporte de la Comunidad Autónoma de La Rioja
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm5008006
Reference31 articles.
1. Distribution of Furamidine Analogues in Tumor Cells: Influence of the Number of Positive Charges
2. DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids
3. A new synthesis of alkene-containing minor-groove binders and essential hydrogen bonding in binding to DNA and in antibacterial activity
4. Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide
5. New Bis(2-aminoimidazoline) and Bisguanidine DNA Minor Groove Binders with Potent in Vivo Antitrypanosomal and Antiplasmodial Activity
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