Tackling Lipophilicity of Peptide Drugs: Replacement of the Backbone N-Methyl Group of Cilengitide by N-Oligoethylene Glycol (N-OEG) Chains
Author:
Affiliation:
1. Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain
2. School of Chemistry & Physics, University of KwaZulua-Natal, 4001 Durban, South Africa
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology
Link
https://pubs.acs.org/doi/pdf/10.1021/bc4003844
Reference48 articles.
1. N-Methylation of Peptides: A New Perspective in Medicinal Chemistry
2. N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions
3. Peptoid-Peptide Hybrid Backbone Architectures
4. Backbone cyclization: A new method for conferring conformational constraint on peptides
5. Site-specific N-alkylation of peptides on the solid phase
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