Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation-Reference-Cited by-同舟云学术

Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues: Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Published:2002-03-13 Issue:8 Volume:45 Page:1697-1711
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Le¹,Woods Keith W.¹,Li Qun¹,Barr Kenneth J.¹,McCroskey Richard W.¹,Hannick Steven M.¹,Gherke Laura¹,Credo R. Bruce¹,Hui Yu-Hua¹,Marsh Kennan¹,Warner Robert¹,Lee Jang Y.¹,Zielinski-Mozng Nicolette¹,Frost David¹,Rosenberg Saul H.¹,Sham Hing L.¹

Affiliation:

1. Global Pharmaceutical R & D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6101

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010523x

Reference32 articles.

1. (a) Boye, O.; Brossi, A. InThe Alkaloids; Brossi, A., Cordell, G. A., Eds.; Academic: New York, 1992; Vol. 41, pp 125−178.

2. Podophyllotoxin, steganacin and combretastatin: Natural products that bind at the colchicine site of tubulin

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