Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors

Published:2007-08-15 Issue:18 Volume:50 Page:4351-4373
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Potashman Michele H.¹,Bready James¹,Coxon Angela¹,DeMelfi, Thomas M.¹,DiPietro Lucian¹,Doerr Nicholas¹,Elbaum Daniel¹,Estrada Juan¹,Gallant Paul¹,Germain Julie¹,Gu Yan¹,Harmange Jean-Christophe¹,Kaufman Stephen A.¹,Kendall Rick¹,Kim Joseph L.¹,Kumar Gondi N.¹,Long Alexander M.¹,Neervannan Seshadri¹,Patel Vinod F.¹,Polverino Anthony¹,Rose Paul¹,van der Plas Simon¹,Whittington Douglas¹,Zanon Roger¹,Zhao Huilin¹

Affiliation:

1. Department of Medicinal Chemistry, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, and Oncology Research, Pharmaceutics, and Pharmacokinetic Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070034i

Reference29 articles.

1. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications

2. Angiogenesis and arthritis

3. Clinical applications of angiogenic growth factors and their inhibitors

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