Aminodeoxychorismate Synthase Inhibitors from One-Bead One-Compound Combinatorial Libraries:  “Staged” Inhibitor Design

Author:

Dixon Seth1,Ziebart Kristin T.1,He Ze1,Jeddeloh Melissa1,Yoo Choong Leol1,Wang Xiaobing1,Lehman Alan1,Lam Kit S.1,Toney Michael D.1,Kurth Mark J.1

Affiliation:

1. Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, Department of Chemistry, Central Connecticut State University, 1615 Stanley Street, New Britain, Connecticut 06050, and Department of Internal Medicine, Division of Hematology and Oncology, UC Davis Cancer Center, 4501 X Street, Sacramento, California 95817

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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1. Unraveling the Structure and Mechanism of the MST(ery) Enzymes;Trends in Biochemical Sciences;2018-05

2. Bead-based screening in chemical biology and drug discovery;Chemical Communications;2018

3. Comparative studies of the catalytic mechanisms of two chorismatases: CH-fkbo and CH-Hyg5;Proteins: Structure, Function, and Bioinformatics;2017-03-24

4. An Open and Shut Case: The Interaction of Magnesium with MST Enzymes;Journal of the American Chemical Society;2016-07-19

5. Peptides and Peptide Analogs to Inhibit Protein-Protein Interactions;Advances in Experimental Medicine and Biology;2016

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