Drug–Polymer–Water Interaction and Its Implication for the Dissolution Performance of Amorphous Solid Dispersions

Author:

Chen Yuejie1,Liu Chengyu1,Chen Zhen1,Su Ching2,Hageman Michael2,Hussain Munir3,Haskell Roy4,Stefanski Kevin2,Qian Feng1

Affiliation:

1. Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Tsinghua University, Beijing 100084, China

2. Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Lawrenceville, New Jersey 08648, United States

3. Drug Product Science and Technology, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903, United States

4. Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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