Retention of Immunosuppressant Activity in an Ascomycin Analogue Lacking a Hydrogen-Bonding Interaction with FKBP12

Author:

Wiedeman Paul E.1,Fesik Stephen W.1,Petros Andrew M.1,Nettesheim David G.1,Mollison Karl W.1,Lane Benjamin C.1,Or Yat Sun1,Luly Jay R.1

Affiliation:

1. Abbott Laboratories, Pharmaceutical Products Division, 200 Abbott Park Road, Department 47N, Building AP-52N, Abbott Park, Illinois 60064-6217

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation;Frontiers in Cell and Developmental Biology;2021-06-22

2. Evaluation, synthesis and characterization of tacrolimus impurities;The Journal of Antibiotics;2012-04-18

3. Chemistry of the Immunomodulatory Macrolide Ascomycin and Related Analogues;Progress in the Chemistry of Organic Natural Products Vol. 94;2011

4. First chemoenzymatic synthesis of immunomodulating macrolactam pimecrolimus;Tetrahedron Letters;2009-07

5. Natural products as immunosuppressive agents;Natural Product Reports;2001

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