1. Department of Analytical Biochemistry, University Centre for Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands, Department of Pathology and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands, and Analytical Biosciences, LACDR, University of Leiden, Einsteinweg 55, 2333 CC Leiden, The Netherlands