Molecular Basis for the Long Duration of Action and Kinetic Selectivity of Tiotropium for the Muscarinic M3 Receptor-Reference-Cited by-同舟云学术

Molecular Basis for the Long Duration of Action and Kinetic Selectivity of Tiotropium for the Muscarinic M3 Receptor

Published:2013-10-25 Issue:21 Volume:56 Page:8746-8756
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tautermann Christofer S.¹,Kiechle Tobias¹,Seeliger Daniel¹,Diehl Sonja¹,Wex Eva¹,Banholzer Rolf¹,Gantner Florian¹,Pieper Michael P.¹,Casarosa Paola¹

Affiliation:

1. Lead Identification and Optimization Support, ‡Respiratory Diseases Research, and §Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397 Biberach, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401219y

Reference50 articles.

1. Molecular Biology of Muscarinic Acetylcholine Receptors

2. The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

3. G-protein-coupled receptor-focused drug discovery using a target class platform approach

4. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management and Prevention of COPD.http://www.goldcopd.org/guidelines-global-strategy-for-diagnosis-management.html(updated 2013) .

5. Novel long-acting bronchodilators for COPD and asthma

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