Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase-Reference-Cited by-同舟云学术

Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase

Published:2014-01-23 Issue:3 Volume:57 Page:1079-1089
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Otrubova Katerina¹,Cravatt Benjamin F.¹,Boger Dale L.¹

Affiliation:

1. Department of Chemistry, ‡Chemical Physiology, and §The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401820q

Reference117 articles.

1. Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

2. The Endocannabinoid System: Drug Targets, Lead Compounds, and Potential Therapeutic Applications

3. Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

4. Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

5. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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