Where Has My Acid Gone? Understanding the Self-Catalyzed Esterification of Maleic Acid in Methanol During Salt Formation
Author:
Affiliation:
1. Pharmaceutical Development, AstraZeneca R&D, Silk Road Business Park, Charter Way, Macclesfield, Cheshire SK10 2NA, U.K.
2. Pharmaceutical Development, AstraZeneca India Pvt. Ltd., Bellary Road, Hebbal, Bangalore 560024, India
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op3001959
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1. Reductive amination of ethyl 2-oxo-4-phenylbutanoate with L-alanyl-L-proline. Synthesis of enalapril maleate
2. Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents
3. Esterification of maleic acid with ethanol over cation-exchange resin catalysts
4. Selective monoesterification of dicarboxylic acids catalysed by ion-exchange resins
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