Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure−Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug-Reference-Cited by-同舟云学术

Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure−Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug

Published:2009-01-06 Issue:3 Volume:52 Page:610-625
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hayashi Shigeo¹,Hirao Akiko¹,Imai Aki¹,Nakamura Hiroshi¹,Murata Yoshinori¹,Ohashi Katsuyo¹,Nakata Eriko¹

Affiliation:

1. Pfizer Global Research & Development Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi 470-2393, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm7012979

Reference64 articles.

1. bThe present article is also the first original report of the synthetic study of MCOPPB and its analogues herein.

2. cThe details of a study of NOP receptor agonist as analgesic with a different series of analogues including those in ref1awill be reported ( Hayashi, S.; et al.).

3. aThe details of the SAR study of the NOP agonists in this article for potent anxiolytic activity, little hERG binding affinity, and metabolic stability will be reported as a subsequent article. ( Hayashi, S.; et al.).

4. bSee also ref61.

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