1. Encysive Pharmaceuticals Inc., 7000 Fannin Street, Houston, Texas 77030, Pharmacological Sciences, College of Pharmacy, University of Houston, 4800 Calhoun Road, Houston, Texas 77204, Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, People's Republic of China