Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity-Reference-Cited by-同舟云学术

Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Published:2005-08-06 Issue:18 Volume:48 Page:5639-5643
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wittman Mark¹,Carboni Joan¹,Attar Ricardo¹,Balasubramanian Balu¹,Balimane Praveen¹,Brassil Patrick¹,Beaulieu Francis¹,Chang Chiehying¹,Clarke Wendy¹,Dell Janet¹,Eummer Jeffrey¹,Frennesson David¹,Gottardis Marco¹,Greer Ann¹,Hansel Steven¹,Hurlburt Warren¹,Jacobson Bruce¹,Krishnananthan Subramaniam¹,Lee Francis Y.¹,Li Aixin¹,Lin Tai-An¹,Liu Peiying¹,Ouellet Carl¹,Sang Xiaopeng¹,Saulnier Mark G.¹,Stoffan Karen¹,Sun Yax¹,Velaparthi Upender¹,Wong Henry¹,Yang Zheng¹,Zimmermann Kurt¹,Zoeckler Mary¹,Vyas Dolatrai¹

Affiliation:

1. Discovery Chemistry, Department of Metabolism and Pharmacokinetics, Department of Computer Aided Drug Design, and Department of Chemical Synthesis, Bristol-Myers Squibb Co, 5 Research Parkway, Wallingford, Connecticut 06492, Discovery Chemistry, Bristol-Myers Squibb Co, Candiac, Quebec, Canada, and Department of Oncology Drug Discovery, Department of Metabolism and Pharmacokinetics, Department of Macromolecular Structure, Bristol-Myers Squibb Co, Route 206 and Province Line Road, Princeton, New Jersey 08540

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050392q

Reference23 articles.

1. The role of insulin-like growth factor I and its receptor in cell growth, transformation, apoptosis, and chemoresistance in solid tumors

2. The PI3K–PDK1 connection: more than just a road to PKB

3. Circulating concentrations of insulin-like growth factor I and risk of breast cancer

Cited by 128 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Drug Repositioning of Inflammatory Bowel Disease Based on Co-Target Gene Expression Signature of Glucocorticoid Receptor and TET2;Biology;2024-01-29

2. Using alternative SMILES representations to identify novel functional analogues in chemical similarity vector searches;Patterns;2023-12

3. The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice;Cell Metabolism;2022-12

4. The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides;International Journal of Molecular Sciences;2022-07-14

5. Applying Nanotechnology in the Synthesis of Benzimidazole Derivatives: A Pharmacological Approach;BIOINTERFACE RES APP;2022