Conformational Landscape of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Non-Nucleoside Inhibitor Binding Pocket: Lessons for Inhibitor Design from a Cluster Analysis of Many Crystal Structures-Reference-Cited by-同舟云学术

Conformational Landscape of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Non-Nucleoside Inhibitor Binding Pocket: Lessons for Inhibitor Design from a Cluster Analysis of Many Crystal Structures

Published:2009-09-08 Issue:20 Volume:52 Page:6413-6420
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Paris Kristina A.¹²,Haq Omar¹²,Felts Anthony K.¹²,Das Kalyan¹³,Arnold Eddy¹³,Levy Ronald M.¹²

Affiliation:

1. Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854

2. BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey 08854

3. Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900854h

Reference39 articles.

1. Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

2. Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase

3. Steered Molecular Dynamics Simulation on the Binding of NNRTI to HIV-1 RT

4. Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase

5. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

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