Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1-Reference-Cited by-同舟云学术

Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1

Published:2005-11-09 Issue:25 Volume:48 Page:8045-8054
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Napper Andrew D.¹,Hixon Jeffrey¹,McDonagh Thomas¹,Keavey Kenneth¹,Pons Jean-Francois¹,Barker Jonathan¹,Yau Wei Tsung¹,Amouzegh Patricia¹,Flegg Adam¹,Hamelin Estelle¹,Thomas Russell J.¹,Kates Michael¹,Jones Stephen¹,Navia Manuel A.¹,Saunders Jeffrey O.¹,DiStefano Peter S.¹,Curtis Rory¹

Affiliation:

1. Elixir Pharmaceuticals, One Kendall Square, Cambridge, Massachusetts 02139, EvotecOAI, 151 Milton Park, Abingdon OX14 4SD, U.K., and Advanced Synthesis Group, Newark, Delaware 19711

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050522v

Reference39 articles.

1. The Sir2 Family of Protein Deacetylases

2. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase

3. The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

4. Erratum: corrigendum: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

5. Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State

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