1. The symbols Pn, Pi, Pii, Pz, P+, and P- refer respectively to the partition coefficients of the neutral molecule, the singly charged ion, the doubly changed ion, the neutral form of an amino acid in equilibrium with the corresponding zwitterion, the cation of an amino acid, and the anion of an amino acid.
2. The distribution coefficient, D, takes into account all forms (neutral and ionic) and is measured or calculated at a particular pH. The distribution profile is a graph of log D over a range of pH values.
3. Quantitative Structure-Activity Relationships of Drugs;Austel,1983
4. Use of distribution coefficients in quantitative structure-activity relations
5. Ionization Constants by Curve Fitting: Determination of Partition and Distribution Coefficients of Acids and Bases and Their Ions