Importance of Ligand Bioactive Conformation in the Discovery of Potent Indole-Diamide Inhibitors of the Hepatitis C Virus NS5B-Reference-Cited by-同舟云学术

Importance of Ligand Bioactive Conformation in the Discovery of Potent Indole-Diamide Inhibitors of the Hepatitis C Virus NS5B

Published:2010-10-13 Issue:43 Volume:132 Page:15204-15212
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

LaPlante Steven R.¹,Gillard James R.¹,Jakalian Araz¹,Aubry Norman¹,Coulombe René¹,Brochu Christian¹,Tsantrizos Youla S.¹,Poirier Martin¹,Kukolj George¹,Beaulieu Pierre L.¹

Affiliation:

1. Departments of Chemistry and Biological Sciences, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard St., Laval, Quebec, Canada, H7S2G5

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja101358s

Reference65 articles.

1. Implications of protein flexibility for drug discovery

2. Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis

3. Conformational selection or induced fit: A flux description of reaction mechanism

4. The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding

5. Residual dipolar couplings as a tool to study molecular recognition of ubiquitin

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