5-Substituted N4-Hydroxy-2‘-deoxycytidines and Their 5‘-Monophosphates: Synthesis, Conformation, Interaction with Tumor Thymidylate Synthase, and in Vitro Antitumor Activity-Reference-Cited by-同舟云学术

5-Substituted N4-Hydroxy-2‘-deoxycytidines and Their 5‘-Monophosphates: Synthesis, Conformation, Interaction with Tumor Thymidylate Synthase, and in Vitro Antitumor Activity

Published:2000-11-01 Issue:24 Volume:43 Page:4647-4656
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Felczak Krzysztof¹,Miazga Agnieszka¹,Poznański Jarosław¹,Bretner Maria¹,Kulikowski Tadeusz¹,Dzik Jolanta M.¹,Gołos Barbara¹,Zieliński Zbigniew¹,Cieśla Joanna¹,Rode Wojciech¹

Affiliation:

1. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5a Pawińskiego Street, 02-106 Warszawa, Poland, and Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warszawa, Poland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000975u

Reference44 articles.

1. THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

2. Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP.

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