Discovery of a Novel Series of Benzoic Acid Derivatives as Potent and Selective Human β3 Adrenergic Receptor Agonists with Good Oral Bioavailability. 3. Phenylethanolaminotetraline (PEAT) Skeleton Containing Biphenyl or Biphenyl Ether Moiety-Reference-Cited by-同舟云学术

Discovery of a Novel Series of Benzoic Acid Derivatives as Potent and Selective Human β3 Adrenergic Receptor Agonists with Good Oral Bioavailability. 3. Phenylethanolaminotetraline (PEAT) Skeleton Containing Biphenyl or Biphenyl Ether Moiety

Published:2008-07-24 Issue:15 Volume:51 Page:4804-4822
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Imanishi Masashi¹,Nakajima Yutaka¹,Tomishima Yasuyo¹,Hamashima Hitoshi¹,Washizuka Kenichi¹,Sakurai Minoru¹,Matsui Shigeo¹,Imamura Emiko¹,Ueshima Koji¹,Yamamoto Takao¹,Yamamoto Nobuhiro¹,Ishikawa Hirofumi¹,Nakano Keiko¹,Unami Naoko¹,Hamada Kaori¹,Matsumura Yasuhiro¹,Takamura Fujiko¹,Hattori Kouji¹

Affiliation:

1. Chemistry Research Laboratories, Pharmacological Research Laboratories, Applied Pharmacology Research Laboratories, and Analysis & Pharmacokinetic Research Laboratories, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800222k

Reference29 articles.

1. Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

2. Molecular Characterization of the Human β 3 -Adrenergic Receptor

3. Beta3 -Adrenoceptor Agonists as Anti-diabetic and Anti-obesity Drugs in Humans

4. STRUCTURE AND FUNCTION OF THE β3-ADRENERGIC RECEPTOR

5. Functional and Molecular Characterization of β-Adrenoceptors in the Internal Anal Sphincter

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