Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells-Reference-Cited by-同舟云学术

Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells

Published:2013-03-13 Issue:6 Volume:56 Page:2695-2699
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

O’Reilly Matthew C.,Scott Sarah A.,Brown Kyle A.,Oguin Thomas H.¹,Thomas Paul G.¹,Daniels J. Scott,Morrison Ryan,Brown H. Alex,Lindsley Craig W.

Affiliation:

1. Department of Immunology, St. Jude Children’s Hospital, Memphis, Tennessee 38105, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301782e

Reference18 articles.

1. Phospholipase D: Enzymology, Functionality, and Chemical Modulation

2. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

3. Biochemical Analysis of Phospholipase D

4. Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

5. Overexpression of phospholipase D1 in human breast cancer tissues

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