1. Department of Pharmacy, Eberhard Karls University, Auf der Morgenstelle 8, D-72076 Tübingen, Germany, Center for Bioinformatics, Eberhard Karls University, Sand 14, D-72076 Tübingen, Germany, Department of Pharmacy, Johannes Gutenberg University, Staudingerweg 5, D-55099 Mainz, Germany, and ProQinase GmbH, Breisacherstrasse 117, D-79106 Freiburg, Germany