A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease-Reference-Cited by-同舟云学术

A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease

Published:2007-04-07 Issue:9 Volume:50 Page:2127-2136
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Burnett James C.¹,Opsenica Dejan¹,Sriraghavan Kamaraj¹,Panchal Rekha G.¹,Ruthel Gordon¹,Hermone Ann R.¹,Nguyen Tam L.¹,Kenny Tara A.¹,Lane Douglas J.¹,McGrath Connor F.¹,Schmidt James J.¹,Vennerstrom Jonathan L.¹,Gussio Rick¹,Šolaja Bogdan A.¹,Bavari Sina¹

Affiliation:

1. SAIC-Frederick, Inc., Target Structure-Based Drug Discovery Group, Frederick, Frederick, Inc., National Cancer Institute at Frederick, P.O. Box B, F.V.C. 310, Frederick, Maryland 21702, The Institute of Chemistry, Technology, and Metallurgy, Njegoševa 12, YU-11001 Belgrade, Serbia, College of Pharmacy, 986025 University of Nebraska Medical Center, Omaha, Nebraska 68198, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, 1425 Porter Street, Frederick, Maryland 21702, Developmental...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061446e

Reference60 articles.

1. Botulinum Toxin as a Biological Weapon

2. Therapy and prophylaxis of inhaled biological toxins

3. The evolving field of biodefence: therapeutic developments and diagnostics

4. The Medicinal Chemistry of Botulinum, Ricin and Anthrax Toxins

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