1. Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, 62032 Camerino (MC), Department of Pharmaceutical Sciences, University of Modena, Via Campi 183, 41100 Modena, Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, and Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy