Novel Mechanism for Dehalogenation and Glutathione Conjugation of Dihalogenated Anilines in Human Liver Microsomes: Evidence for ipso Glutathione Addition

Author:

Zhang Chenghong,Kenny Jane R.,Le Hoa,Deese Alan,Ford Kevin A.,Lightning Luke K.1,Fan Peter W.,Driscoll James P.,Halladay Jason S.,Hop Cornelis E. C. A.,Khojasteh S. Cyrus

Affiliation:

1. Alquest Therapeutics, 100 St. Albans Road, Kensington, California 94708, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

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1. Halogens in Seaweeds: Biological and Environmental Significance;Phycology;2022-02-18

2. Strategies to Mitigate the Bioactivation of Aryl Amines;Chemical Research in Toxicology;2020-06-08

3. The use of stable isotopes in drug metabolism studies;Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters;2020

4. Design of Radioiodinated Pharmaceuticals: Structural Features Affecting Metabolic Stability towards in Vivo Deiodination;European Journal of Organic Chemistry;2017-04-26

5. Phase I Metabolic Stability and Electrophilic Reactivity of 2-Phenylaminophenylacetic Acid Derived Compounds;Chemical Research in Toxicology;2016-06-14

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