Design and Synthesis of Novel Biologically Active Thrombin Receptor Non-Peptide Mimetics Based on the Pharmacophoric Cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence: Platelet Aggregation and Relaxant Activities-Reference-Cited by-同舟云学术

Design and Synthesis of Novel Biologically Active Thrombin Receptor Non-Peptide Mimetics Based on the Pharmacophoric Cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence: Platelet Aggregation and Relaxant Activities

Published:2004-05-19 Issue:13 Volume:47 Page:3338-3352
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Alexopoulos Kostas¹,Fatseas Panagiotis¹,Melissari Euthemia¹,Vlahakos Demetrios¹,Roumelioti Panagiota¹,Mavromoustakos Thomas¹,Mihailescu Stefan¹,Paredes-Carbajal Maria Christina¹,Mascher Dieter¹,Matsoukas John¹

Affiliation:

1. Department of Chemistry, University of Patras, Patras 26110, Greece, Blood Department, Agios Andreas Hospital, Patras 26335, Greece, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, Athens 17674, Greece, National Hellenic Research Foundation, Institute of Organic and Pharmaceutical Chemistry, Vas. Constantinou 48 Avenue, Athens 11635, Greece, Department of Physiology, Faculty of Medicine, University of Craiova, Craiova, RO-1100, Romania, and Department of Physiology, School of Medicine, Universidad...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm031080v

Reference42 articles.

1. Characterization of a functional thrombin receptor. Issues and opportunities.

2. Thrombin Receptor Antagonists

3. Cellular consequences of thrombin-receptor activation

4. Locating ligand-binding sites in 7tm receptors by protein engineering

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