Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities-Reference-Cited by-同舟云学术

Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities

Published:2002-12-05 Issue:1 Volume:46 Page:74-86
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Venhorst Jennifer¹,ter Laak Antonius M.¹,Commandeur Jan N. M.¹,Funae Yoshihiko¹,Hiroi Toyoko¹,Vermeulen Nico P. E.¹

Affiliation:

1. Department of Pharmacochemistry, Faculty of Sciences, Division of Molecular Toxicology, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands, and Laboratory of Chemistry, Osaka University Medical School, 1-4-54, Asahimachi, Abeno-ku, Osaka 545, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0209578

Reference53 articles.

1. Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

2. Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment

3. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

4. Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression

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