Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket-Reference-Cited by-同舟云学术

Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

Published:2011-03-29 Issue:8 Volume:54 Page:2727-2737
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Das Kalyan,Bauman Joseph D.,Rim Angela S.,Dharia Chhaya,Clark Arthur D.,Camarasa María-José¹,Balzarini Jan²,Arnold Eddy

Affiliation:

1. Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101536x

Reference55 articles.

1. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): Past, Present, and Future

2. The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.

3. Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms

4. Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

5. Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097

Cited by 70 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 1,5-disubstituted 1,2,3-triazolylated carbohydrates and nucleosides;Carbohydrate Research;2024-07

2. A nanoemulsified formulation of dolutegravir and epigallocatechin gallate inhibits HIV‐1 replication in cellular models;FEBS Letters;2024-05-24

3. 1,2,3-Triazolyl Phenylhydrazones as Antioxidant Agents: An Ultrasound Promoted Catalyst-Free Synthesis and Molecular Docking Study;Polycyclic Aromatic Compounds;2024-02-13

4. Synthesis, characterization, cytotoxic evaluation, and molecular docking studies of novel 1,2,3-triazole-based chalcones for potential anticancer applications;Results in Chemistry;2024-01

5. Role of diosgenin extracted from Helicteres isora L in suppression of HIV-1 replication: An in vitro preclinical study;Heliyon;2024-01