Extracellular Microvesicles Modified with Arginine-Rich Peptides for Active Macropinocytosis Induction and Delivery of Therapeutic Molecules

Author:

Morimoto Kenta1,Ishitobi Jojiro1,Noguchi Kosuke1,Kira Ryoichi1,Kitayama Yukiya2,Goto Yuto2,Fujiwara Daisuke1,Michigami Masataka1,Harada Atsushi2ORCID,Takatani-Nakase Tomoka34ORCID,Fujii Ikuo1,Futaki Shiroh5ORCID,Kanada Masamitsu67ORCID,Nakase Ikuhiko1ORCID

Affiliation:

1. Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, 1-1, Gakuen-cho, Naka-ku, Sakai 599-8531, Osaka, Japan

2. Department of Applied Chemistry, Graduate School of Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai 599-8531, Osaka, Japan

3. Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, 11-68, Koshien Kyuban-cho, Nishinomiya 663-8179, Hyogo, Japan

4. Institute for Bioscience, Mukogawa Women’s University, 11-68, Koshien Kyuban-cho, Nishinomiya 663-8179, Hyogo, Japan

5. Institute for Chemical Research, Kyoto University, Uji 611-0011, Kyoto, Japan

6. Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, Michigan 48824, United States

7. Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, United States

Funder

Naito Foundation

Takeda Science Foundation

Core Research for Evolutional Science and Technology

Institute for Chemical Research, Kyoto University

Osaka Metropolitan University

Publisher

American Chemical Society (ACS)

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