Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors

Published:2010-07-14 Issue:15 Volume:53 Page:5629-5638
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hamada Shohei¹,Suzuki Takayoshi¹²,Mino Koshiki³,Koseki Koichi³,Oehme Felix⁴,Flamme Ingo⁴,Ozasa Hiroki¹,Itoh Yukihiro¹,Ogasawara Daisuke¹,Komaarashi Haruka³,Kato Aiko³,Tsumoto Hiroki¹,Nakagawa Hidehiko¹,Hasegawa Makoto³,Sasaki Ryuzo⁵,Mizukami Tamio³,Miyata Naoki¹

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan

2. PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan

3. Graduate School of Bio-Science, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga 526-0829, Japan

4. Bayer Schering Pharma AG, Institute for Cardiovascular Research, Aprather Weg 18a, D-42096 Wuppertal, Germany

5. Frontier Pharma Inc., 1281-8 Tamura-cho, Nagahama, Shiga 526-0829, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1003655

Reference23 articles.

1. A Crack in Histone Lysine Methylation

2. Reversing histone methylation

3. Histone lysine demethylases: emerging roles in development, physiology and disease

4. Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

5. A Novel Mammalian Flavin-dependent Histone Demethylase

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