Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia-Reference-Cited by-同舟云学术

Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Published:2012-10-08 Issue:20 Volume:55 Page:8721-8734
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bavetsias Vassilios¹,Crumpler Simon¹,Sun Chongbo¹,Avery Sian¹,Atrash Butrus¹,Faisal Amir¹,Moore Andrew S.¹,Kosmopoulou Magda²,Brown Nathan¹,Sheldrake Peter W.¹,Bush Katherine¹,Henley Alan¹,Box Gary¹,Valenti Melanie¹,de Haven Brandon Alexis¹,Raynaud Florence I.¹,Workman Paul¹,Eccles Suzanne A.¹,Bayliss Richard²,Linardopoulos Spiros¹³,Blagg Julian¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom

2. Division of Structural Biology, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, United Kingdom

3. The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300952s

Reference65 articles.

1. The cellular geography of Aurora kinases

2. Aurora kinases in spindle assembly and chromosome segregation

3. Aurora-A — A guardian of poles

4. Aurora-A: the maker and breaker of spindle poles

5. Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

Cited by 65 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Reaction Pattern and Mechanistic Aspects of Iodine and Iodine-Based Reagents in Selenylation of Aliphatic, Aromatic, and (Hetero)Cyclic Systems;Topics in Current Chemistry;2024-04-08

2. Novel sulfonamides unveiled as potent anti-lung cancer agents via tumor pyruvate kinase M2 activation;RSC Medicinal Chemistry;2024

3. Exploration De L'Ouverture Du Pyranopyrazole Pour La Synthèse De Dérivés Pyrazoliques: Conception, Synthèse, Amarrage Moléculaire, Simulation Dynamique Moléculaire Et Analyses Dft;2024

4. A novel class of pyrazole analogues as aurora kinase A inhibitor: design, synthesis, and anticancer evaluation;Bioorganic Chemistry;2023-12

5. Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review;Bioorganic Chemistry;2023-11