Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Group on Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity-Reference-Cited by-同舟云学术

Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Group on Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity

Published:2008-08-30 Issue:18 Volume:51 Page:5650-5662
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dawson Marcia I.¹,Xia Zebin¹,Jiang Tao¹,Ye Mao¹,Fontana Joseph A.¹,Farhana Lulu¹,Patel Bhaumik¹,Xue Li Ping¹,Bhuiyan Mohammad¹,Pellicciari Roberto¹,Macchiarulo Antonio¹,Nuti Roberto¹,Zhang Xiao-Kun¹,Han Young-Hoon¹,Tautz Lutz¹,Hobbs Peter D.¹,Jong Ling¹,Waleh Nahid¹,Chao Wan-ru¹,Feng Gen-Sheng¹,Pang Yuhong¹,Su Ying¹

Affiliation:

1. Cancer Center and Inflammatory and Infectious Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, Wayne State University School of Medicine and Department of Veterans Affairs, Detroit, Michigan 48201, Universita’ degli Studi di Perugia, Perugia, Italy, and SRI International, Menlo Park, California 94025

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800456k

Reference54 articles.

1. Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog

2. Antagonist Analogue of 6-[3‘-(1-Adamantyl)-4‘-hydroxyphenyl]-2-naphthalenecarboxylic Acid (AHPN) Family of Apoptosis Inducers That Effectively Blocks AHPN-Induced Apoptosis but Not Cell-Cycle Arrest

3. Apoptosis Induction by a Novel Retinoid-Related Molecule Requires Nuclear Factor-κB Activation

4. An Adamantyl-Substituted Retinoid-Derived Molecule That Inhibits Cancer Cell Growth and Angiogenesis by Inducing Apoptosis and Binds to Small Heterodimer Partner Nuclear Receptor: Effects of Modifying Its Carboxylate Group on Apoptosis, Proliferation, and Protein-Tyrosine Phosphatase Activity

5. Adamantyl-Substituted Retinoid-Related Molecules Bind Small Heterodimer Partner and Modulate the Sin3A Repressor

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