Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of Benzylamino and Alkylamino Ether Analogues of Artemisinin-Reference-Cited by-同舟云学术

Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of Benzylamino and Alkylamino Ether Analogues of Artemisinin

Published:1996-01-01 Issue:22 Volume:39 Page:4511-4514
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

O'Neill Paul M.¹,Bishop Laurence P.¹,Storr Richard C.¹,Hawley Shaun R.¹,Maggs James L.¹,Ward Stephen A.¹,Park B. Kevin¹

Affiliation:

1. Departments of Chemistry and of Pharmacology and Therapeutics, The University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9604944

Reference18 articles.

1. Qinghaosu (Artemisinin): an Antimalarial Drug from China

2. Reaction of antimalarial endoperoxides with specific parasite proteins

3. Regiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu).

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