6-Azapyrimidine-2‘-deoxy-4‘-thionucleosides: Antiviral Agents against TK+ and TK− HSV and VZV Strains-Reference-Cited by-同舟云学术

6-Azapyrimidine-2‘-deoxy-4‘-thionucleosides: Antiviral Agents against TK+ and TK− HSV and VZV Strains

Published:2004-09-29 Issue:22 Volume:47 Page:5482-5491
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Maslen Hannah L.¹,Hughes David¹,Hursthouse Mike¹,De Clercq Erik¹,Balzarini Jan¹,Simons Claire¹

Affiliation:

1. Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK; EPSRC X-ray Crystallography Service, Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK; and Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049806q

Reference34 articles.

1. Simons, C.Nucleoside Mimetics: Their Chemistry and Biological Properties; Gordon and Breach Science Publishers: Amsterdam; Advanced Chemistry Texts, 2001; Vol. 3.

2. Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia

3. Suhadolnik, R. J.Nucleoside Antibiotics; Wiley-Interscience: New York, 1979.

4. In vitro and in vivo antiviral (RNA) evaluation of orotidine 5′-monophosphate decarboxylase inhibitors and analogues including 6-azauridine-5′-(ethyl methoxyalaninyl)phosphate (a 5′-monophosphate prodrug)

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