1. Medicinal Chemistry, Department of Pharmacy & Pharmacology and Sterix Limited, University of Bath, Claverton Down, Bath, BA2 7AY, U.K., Endocrinology & Metabolic Medicine and Sterix Limited, Faculty of Medicine, Imperial College, St. Mary's Hospital, London, W2 1NY, U.K., and Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, U.K.