Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies-Reference-Cited by-同舟云学术

Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies

Published:2008-09-11 Issue:19 Volume:51 Page:6021-6033
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ghosh Arun K.¹,Gemma Sandra¹,Baldridge Abigail¹,Wang Yuan-Fang¹,Kovalevsky Andrey Yu.¹,Koh Yashiro¹,Weber Irene T.¹,Mitsuya Hiroaki¹

Affiliation:

1. Departments of Chemistry and Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, Georgia 30303, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan, Department of Hematology and Infectious Diseases, Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8004543

Reference44 articles.

1. AIDS — The First 20 Years

2. Why do patients fail HIV therapy?

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4. Factors associated with clinical and virological failure in patients receiving a triple therapy including a protease inhibitor

5. Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance

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