Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models-Reference-Cited by-同舟云学术

Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models

Published:2008-08-21 Issue:18 Volume:51 Page:5680-5689
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hudkins Robert L.¹,Diebold James L.¹,Tao Ming¹,Josef Kurt A.¹,Park Chung Ho¹,Angeles Thelma S.¹,Aimone Lisa D.¹,Husten Jean¹,Ator Mark A.¹,Meyer Sheryl L.¹,Holskin Beverly P.¹,Durkin John T.¹,Fedorov Alexander A.¹,Fedorov Elena V.¹,Almo Steven C.¹,Mathiasen Joanne R.¹,Bozyczko-Coyne Donna¹,Saporito Michael S.¹,Scott Richard W.¹,Mallamo John P.¹

Affiliation:

1. Discovery Research, Cephalon, Incorporated, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, and Albert Einstein College of Medicine, Bronx, New York 10461

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8005838

Reference43 articles.

1. Mixed-Lineage Kinases: A Target for the Prevention of Neurodegeneration

2. Mixed-lineage kinase control of JNK and p38 MAPK pathways

3. Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential

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