Improved Loading and Cleavage Methods for Solid-Phase Synthesis Using Chlorotrityl Resins: Synthesis and Testing of a Library of 144 Discrete Chemicals as Potential Farnesyltransferase Inhibitors
Author:
Affiliation:
1. Computer-Aided Molecular Design Laboratory, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, and Department of Biochemistry, Duke University Medical Center, 210A Nanaline H. Duke, Durham, North Carolina 27710
Publisher
American Chemical Society (ACS)
Subject
General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/cc0340729
Reference16 articles.
1. THE POTENTIAL OF FARNESYLTRANSFERASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS
2. Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
3. Radiofrequency Encoded Combinatorial Chemistry
4. Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads
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