Cellular Membrane Phospholipids Act as a Depository for Quaternary Amine Containing Drugs thus Competing with the Acetylcholine/Nicotinic Receptor
Author:
Affiliation:
1. Integrative Neuroscience, NIDA IRP, NIH, Baltimore, Maryland 21224, United States
2. Ionwerks Inc., Houston, Texas 77002, United States
Publisher
American Chemical Society (ACS)
Subject
General Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/pr300184g
Reference42 articles.
1. Lipophilicity in drug discovery
2. Interaction of Chlorisondamine with the Neuronal Nicotinic Acetylcholine Receptor
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4. The importance of plasma protein binding in drug discovery
5. Drug–protein binding: a critical review of analytical tools
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