Noncovalent DNA Binding Drives DNA Alkylation by Leinamycin: Evidence That the Z,E-5-(Thiazol-4-yl)-penta-2,4-dienone Moiety of the Natural Product Serves as an Atypical DNA Intercalator-Reference-Cited by-同舟云学术

Noncovalent DNA Binding Drives DNA Alkylation by Leinamycin: Evidence That the Z,E-5-(Thiazol-4-yl)-penta-2,4-dienone Moiety of the Natural Product Serves as an Atypical DNA Intercalator

Published:2011-10-18 Issue:44 Volume:133 Page:17641-17651
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Fekry Mostafa I.¹²,Szekely Jozsef¹,Dutta Sanjay¹,Breydo Leonid¹,Zang Hong¹,Gates Kent S.¹

Affiliation:

1. Departments of Chemistry and Biochemistry, 125 Chemistry Building, University of Missouri−Columbia, Columbia, Missouri 65211, United States

2. Pharmacognosy Department, Kasr El-Aini, Cairo University, Cairo, Egypt 11562

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja2046149

Reference129 articles.

1. An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

2. Sequence-Selective DNA Recognition: Natural Products and Nature’s Lessons

3. DNA and associated targets for drug design

4. Mechanisms of in Situ Activation for DNA-Targeting Antitumor Agents

5. DNA adducts, mutations and cancer

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