Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18. N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure−Activity Relationships-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18. N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure−Activity Relationships

Published:2003-03-29 Issue:9 Volume:46 Page:1758-1763
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Greiner Elisabeth¹,Spetea Mariana¹,Krassnig Roland¹,Schüllner Falko¹,Aceto Mario¹,Harris Louis S.¹,Traynor John R.¹,Woods James H.¹,Coop Andrew¹,Schmidhammer Helmut¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0613, Department of Pharmacology, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, Michigan 48109, and Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine Street, Baltimore,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm021118o

Reference31 articles.

1. The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists.

2. Opioid Analgesics

3. Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones

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